A protein critical to the development and growth of prostate cancer has been discovered by LSU Health Sciences Center researchers. The findings are published online in the Early Edition of Proceedings of the National Academy of Sciences, available the week of February 6, 2012
Dr. Liu and his team discovered a protein called ARD1 which is involved with the male hormone, androgen, and its receptor. Prostate cancer is a hormone-regulated disease and the main hormone is androgen. Androgen activates its receptor - androgen receptor (AR) to play a critical role in the development and progression of prostate cancer. Therefore, androgen deprivation therapy has been a standard treatment for advanced prostate cancer.
"However, a majority of tumors invariably relapse and become an androgen-independent prostate cancer from which most patients eventually die," notes Dr. Liu, who is also a member of the LSUHSC Stanley S. Scott Cancer Center.
To find an alternative strategy to treat prostate cancer, Dr. Liu's group is studying androgen receptor activators and increasing levels of these activators leading to prostate cancer. Following the discovery of this new protein, they determined that ARD1 is overproduced in the majority of prostate cancer samples, that it activates the androgen receptor, and that it is an essential component of prostate cancer cell growth.
"In addition, we demonstrated that inactivation of ARD1 inhibits the function of androgen receptors resulting in complete suppression of prostate cancer cell growth in tissue culture and prostate tumor growth in mice," reports Dr. Liu. "Furthermore, we revealed that the role of ARD1 in the development of prostate cancer is to modify the androgen receptor to enhance its activity."
According to the National Cancer Institute, about 242,000 American men will be diagnosed with prostate cancer this year. It is the second most diagnosed cancer among men, only behind skin cancer. An estimated 28,170 men will die from prostate cancer in 2012.
"Our study provides a novel avenue for controlling AR-mediated prostate tumor development by directly inhibiting the function of ARD1 or AR-ARD1 interaction," says Dr. Liu. "Developing an ARD1-specific inhibitor or an AR-ARD1 interaction-disrupting compound may be of therapeutic benefit in the treatment of prostate cancer."
Source-Eurekalert
1 comment:
Most prostate cancers are adenocarcinomas, cancers that arise in glandular cells of the prostate’s epithelial tissue. Prostate cancers usually progress slowly and produce no symptoms in the initial stages. Eventually, the tumor may enlarge like mine use too, the prostate gland, pressing on the urethra and causing painful or frequent urination and blood in the urine. So I was so uncomfortable with this prostate cancer diseases then I decided to do online search on how to cure cancer because I well have read a lot about herbal medicine, I came across a lot of testimony how Dr Itua cure HIV/herpes then Cancer was listed below the comment.with courage I contacted Dr Itua and he sent me his herbal medicine through Courier service then I was asked to pick it up at my post office which i quickly did. I contacted Dr Itua that i have received my herbal medicine so he instructs me on how to drink it for three weeks and that is how Dr Itua Herbal Medicine cure my prostate Cancer, The treatment takes three weeks and I was cured completely. Dr Itua is a god sent and I thank him every day of my life. Contact him now On:Email:drituaherbalcenter@gmail.com/ Whatsapp:+2348149277967.
He listed to that he can as well cure the following diseases below.... Cerebral Amides. Lung Cancer,Brain cancer,Esophageal cancer,Gallbladder cancer,Gestational trophoblastic disease,Head and neck cancer,Hodgkin lymphoma Intestinal cancer,Kidney cancer,Leukemia,Liver cancer,Melanoma,Mesothelioma,Multiple myeloma,Neuroendocrine tumors,Hodgkin lymphoma,Oral cancer,Ovarian cancer,Sinus cancer,Soft tissue sarcoma,Spinal cancer,Stomach cancer,Testicular cancer,Throat cancer,Thyroid Cancer,Uterine cancer,Vaginal cancer,Vulvar cancer. Alzheimer's disease,Autism,measles, tetanus, whooping cough, tuberculosis, polio and diphtheria Adrenocortical carcinoma. Alma, Uterine Cancer, Breast Cancer, Allergic diseases. Kidney cancer, Love Spell, Glaucoma., Cataracts,Macular degeneration,Cardiovascular disease,Lung disease.Enlarged prostate,Osteoporosis.Generalized dermatitis,Alzheimer's disease,Brain Tumor,Lupus,Endomertil Cancer, cerebrovascular diseases
Dementia.Colo rectal cancer, Lottery Spell, Bladder Cancer, Skin Cancer,Ovarian Cancer,Pancreatic Cancer, HIV /Aids,Brain Tumor, Herpes, Non-Hodgkin lymphoma, Inflammatory bowel disease, Copd, Diabetes, Hepatitis
Post a Comment